The HEART score is one of the most widely used and best-validated clinical decision tools for chest pain in the emergency department. It turns five pieces of information a clinician already gathers — History, ECG, Age, Risk factors, and Troponin — into a single 0–10 number that estimates a patient's short-term cardiac risk.

How the HEART score works

Each of the five components is scored 0, 1, or 2 points based on how strongly it points toward acute coronary syndrome, and the five scores are summed for a total of 0–10. The total places the patient into one of three risk tiers for major adverse cardiac events (MACE) within 6 weeks: Low (0–3), Moderate (4–6), or High (7–10). These tiers and their associated MACE rates were established in the original derivation study by Six et al. (2008) and confirmed in the larger multicenter HEART Pathway validation by Backus et al. (2013).

The five components

History captures how classic the presenting symptoms are for cardiac ischemia — retrosternal pressure radiating to the arm or jaw scores higher than atypical, sharp, or positional pain. ECG scores any ST-segment deviation not otherwise explained highest, nonspecific repolarization changes (e.g., LBBB, LVH, digoxin effect) in the middle, and a normal tracing lowest. Age reflects rising baseline cardiovascular risk with each decade. Risk factors tallies hypertension, hypercholesterolemia, diabetes, obesity, smoking, family history, and known atherosclerotic disease — a patient with established atherosclerotic disease automatically scores the maximum 2 points for this item. Troponin uses the local assay's upper limit of normal as the reference point for scoring an initial (or first available) value.

Scope and limitations

The HEART score was derived and validated specifically for adult (≥21 years) emergency department patients being evaluated for possible acute coronary syndrome — it is not intended for patients who already have a STEMI or who are hemodynamically unstable, both of which require immediate protocol activation regardless of score. The History item is inherently subjective, which introduces some interobserver variability. The HEART Pathway protocol pairs the score with serial troponin testing (commonly at 0 and 3 hours) rather than relying on a single value, and clinical judgment should always be able to override a calculated low-risk score when something about the presentation is concerning.