GLP-1 Weight Loss Projection Calculator

Project your weight loss timeline on GLP-1 medications based on clinical trial data

Medical Disclaimer: This calculator provides educational projections based on published clinical trial averages. It is not medical advice. Consult your healthcare provider before starting any medication. Individual results vary significantly.
Your Profile
Projected Results Semaglutide 2.4mg
Based on STEP & SURMOUNT clinical trial averages
Current Weight 220 lbs
3 Months --
6 Months --
12 Months --
Starting BMI --
Projected BMI --
% Body Weight Lost --

Projected Weight Over 52 Weeks

GLP-1 medications use a dose escalation schedule. Weight loss rates are typically slower during the initial titration phase.

Medication Comparison

Side-by-side projected outcomes based on your profile

All Medications — Projected Weight Over 52 Weeks

Metric Semaglutide 2.4mg Tirzepatide 5mg Tirzepatide 10mg Tirzepatide 15mg

Week-by-Week Timeline

Dose escalation schedule and projected milestones for Semaglutide 2.4mg

Dose Escalation Schedule

Projected Milestones

Weekly Projections

Week Projected Weight Weight Lost % Lost BMI Phase
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Frequently Asked Questions

Basics How much weight can you lose on Ozempic (semaglutide)?
In the STEP 1 clinical trial, participants taking semaglutide 2.4mg weekly lost an average of approximately 15% of their body weight over 68 weeks. For a 220 lb person, this would mean losing roughly 33 lbs. Individual results vary widely based on diet, exercise, starting weight, and other factors.
Basics How does tirzepatide compare to semaglutide?
Tirzepatide (Mounjaro/Zepbound) is a dual GIP/GLP-1 receptor agonist that showed greater weight loss in clinical trials. At the 15mg dose, participants lost approximately 22.5% of body weight at 72 weeks in the SURMOUNT-1 trial, compared to approximately 15% for semaglutide 2.4mg. However, direct head-to-head comparison data is limited.
Basics Why is there a dose escalation period?
GLP-1 medications are started at low doses and gradually increased to minimize gastrointestinal side effects (nausea, vomiting, diarrhea). This titration period typically lasts 16-20 weeks. Weight loss is slower during this phase but accelerates once the maintenance dose is reached.
Basics What happens if you stop taking GLP-1 medications?
Studies, including the STEP 4 trial, show that most people regain a significant portion of lost weight within a year of discontinuing GLP-1 medications. This highlights that these medications manage obesity as a chronic condition rather than providing a permanent cure. Maintaining lifestyle changes can help mitigate weight regain.
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Real-World Examples

👩 Sarah

Example

Scenario A — Semaglutide 2.4mg

A 40-year-old female, 5'5", 210 lbs starting semaglutide 2.4mg. Based on the STEP 1 trial average of ~15% body weight loss: projected weight at 12 months is approximately 179 lbs, with BMI dropping from 34.9 to 29.8.