Not all supplements are created equal, and more is rarely better. Fat-soluble vitamins — A, D, E, and K — accumulate in body fat and the liver. Chronically exceeding the Tolerable Upper Intake Level (UL) for these nutrients can cause serious toxicity. Vitamin A toxicity (hypervitaminosis A) can cause liver damage, bone loss, and birth defects. Vitamin D toxicity causes hypercalcemia, leading to nausea, weakness, and kidney damage.

Water-soluble vitamins like C and the B-complex are generally safer because excess is excreted in urine. However, very high doses of B6 (>100 mg/day long term) can cause peripheral neuropathy, and large doses of niacin (B3) can cause flushing and liver toxicity. Even "safe" minerals like zinc and calcium cause problems in excess — too much zinc inhibits copper absorption, and excess calcium supplementation has been linked to cardiovascular risk.

The safest approach: aim to meet most of your micronutrient needs from food, test for actual deficiencies before supplementing aggressively, and stay well below the UL for fat-soluble vitamins unless supervised by a physician.